Molecular studies on trypanothione reductase, a target for antiparasitic drugs.

Abstract excerpt

Trypanosoma and Leishmania are parasitic protozoa that cause a variety of diseases, which include African sleeping sickness and oriental sore. Attempts to determine pharmaceutically exploitable differences between host and parasite biochemistry have identified the unique trypanothione pathway as a possible target. This pathway includes the enzyme trypanothione reductase, the parasite analogue of glutathione...

Topics

• Animals
• Antiprotozoal Agents
• Drug Design
• Glutathione
• Leishmania
• Mutation
• NADH, NADPH Oxidoreductases
• Spermidine
• Trypanosoma