Article
Risk factors for inhibitor formation in haemophilia: a prevalent case-control study.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Sept 2009
Ragni M V, Ojeifo O, Feng J, Yan J, Hill K A, Sommer S S, Trucco M N, Brambilla D J
Abstract excerpt
Inhibitor formation is a major complication of haemophilia treatment. In a prevalent case-control study, we evaluated blood product exposure, genotype and HLA type on haemophilia A inhibitor formation. Product exposure was extracted from medical records. Genotype was determined on stored DNA samples by detection of virtually all mutations-SSCP (DOVAM-S) and subcycling PCR. HLA typing was performed by PCR...
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