Article
Programmed loss of millions of base pairs from a vertebrate genome.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2009
Smith Jeramiah J, Antonacci Francesca, Eichler Evan E, Amemiya Chris T
Abstract excerpt
In general, the strict preservation of broad-scale structure is thought to be critical for maintaining the precisely tuned functionality of vertebrate genomes, although nearly all vertebrate species undergo a small number of programmed local rearrangements during development (e.g., remodeling of adaptive immune receptor loci). However, a limited number of metazoan species undergo much more extensive...
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