Article
Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Bioorganic & medicinal chemistry letters - 1 Aug 2009
Sablone Manolo Rocco, Cesta Maria Candida, Moriconi Alessio, Aramini Andrea, Bizzarri Cinzia, Di Giacinto Claudia, Di Bitondo Rosa, Gloaguen Isabelle, Aschi Massimiliano, Crucianelli Marcello, Bertini Riccardo, Allegretti Marcello
Abstract excerpt
We reported recently the Structure-Activity Relationship (SAR) of a class of CXCL8 allosteric modulators. They invariably share a 2-arylpropionic moiety so far considered a key structural determinant of the biological activity. We show the results of recent SAR studies on a novel series of phenylacetic derivatives supported by a combined approach of mutagenesis experiments and conformational analysis. The results...
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