Dominant-negative mutants as antiviral agents: simultaneous infection with the cold-adapted live-virus vaccine for influenza A protects ferrets from disease produced by wild-type influenza A.

doi:10.1093/infdis/164.6.1200

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Article

Dominant-negative mutants as antiviral agents: simultaneous infection with the cold-adapted live-virus vaccine for influenza A protects ferrets from disease produced by wild-type influenza A.

The Journal of infectious diseases - 1 Dec 1991

Whitaker-Dowling P, Maassab H F, Youngner J S

Abstract excerpt

The attenuated cold-adapted strain of influenza A virus that is a candidate live-virus vaccine suppressed clinical disease in ferrets when given simultaneously with a virulent epidemic strain of influenza A virus. The cold-adapted virus effectively prevented disease, even when the epidemic strain...

Topics

Animals
Antibodies, Viral
Ferrets
Influenza A virus
Influenza Vaccines
Lung
Mutation
Orthomyxoviridae Infections
Turbinates
Virulence

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