Article
Anthracycline metabolites from Streptomyces violaceus A262. II. New anthracycline epelmycins produced by a blocked mutant strain SU2-730.
The Journal of antibiotics - 1 Oct 1991
Johdo O, Watanabe Y, Ishikura T, Yoshimoto A, Naganawa H, Sawa T, Takeuchi T
Abstract excerpt
New anthracycline antibiotics, identified as epsilon-rhodomycinone glycosides, were isolated from the culture broth of a blocked mutant of beta-rhodomycin-producing Streptomyces violaceus A262. They were designated as epelmycins A, B, C, D and E, and assayed for their in vitro cytotoxicities against murine leukemic L1210 cell culture and the antimicrobial activities in comparison with known anthracycline antibiotics.
Topics
- Animals
- Anthracyclines
- Antibiotics, Antineoplastic
- Bacteria
- Chromatography, High Pressure Liquid
- Chromatography, Thin Layer
- Drug Evaluation, Preclinical
- Fermentation
- Leukemia L1210
- Magnetic Resonance Spectroscopy