Article
Genetic modulation of brugada syndrome by a common polymorphism.
Journal of cardiovascular electrophysiology - 1 Oct 2009
Lizotte Eric, Junttila M Juhani, Dube Marie Pierre, Hong Kui, Benito Begona, DE Zutter Marc, Henkens Stefan, Sarkozy Andrea, Huikuri Heikki V, Towbin Jeffrey, Vatta Matteo, Brugada Pedro, Brugada Josep, Brugada Ramon
Abstract excerpt
BACKGROUND: Brugada syndrome predisposes some subjects to ventricular tachyarrhythmias and sudden cardiac death. Mutations in SCN5A gene have been associated with approximately 25% of Brugada syndrome patients. A common variant in SCN5A, H558R has shown to improve sodium channel activity in mutated channels. We studied whether common variant H558R has any clinical implications in the phenotype of Brugada...
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