Article
Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients.
Journal of the American College of Cardiology - 17 Jul 2002
Smits Jeroen P P, Eckardt Lars, Probst Vincent, Bezzina Connie R, Schott Jean Jacques, Remme Carol Ann, Haverkamp Wilhelm, Breithardt Günter, Escande Denis, Schulze-Bahr Eric, LeMarec Hervé, Wilde Arthur A M
Abstract excerpt
OBJECTIVES: We have tested whether a genotype-phenotype relationship exists in Brugada syndrome (BS) by trying to distinguish BS patients with (carriers) and those without (non-carriers) a mutation in the gene encoding the cardiac sodium channel (SCN5A) using clinical parameters. BACKGROUND: Brugada syndrome is an inherited cardiac disease characterized by a varying degree of ST-segment elevation in the right...
Topics
- Adult
- Anti-Arrhythmia Agents
- Bundle-Branch Block
- DNA Mutational Analysis
- Electrocardiography
- Female
- Genotype
- Heterozygote
- Humans
- Male