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Article

A combinatorial mechanism for determining the specificity of E2F activation and repression.

Oncogene - 13 Aug 2009

Freedman J A, Chang J T, Jakoi L, Nevins J R

Abstract excerpt

Various studies have detailed the role of E2F proteins in both transcription activation and repression. Further study has shown that distinct promoter elements, but comprising the same E2F-recognition motif, confer positive or negative E2F control and that this reflects binding of either activator or repressor E2F proteins, respectively. We now show that the specificity of binding of an activator or repressor E2F...

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Identifiers

PMID: 19543322
DOI: 10.1038/onc.2009.153
PMCID: PMC2726897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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