Spheroid‐forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry <i>via</i> hsa‐miR‐299–5p regulated <i>de novo</i> expression of osteopontin

Abstract excerpt

The growth of cancer cells as multicellular spheroids has frequently been reported to mimic the in vivo tumour architecture and physiology and has been utilized to study antitumour drugs. In order to determine the distinctive characteristics of the spheroid-derived cells compared to the corresponding monolayer-derived cells, we enriched multicellular spheroid-forming subpopulations of cells from three human...

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