Article
A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis.
Neuromolecular medicine - 1 Jan 2009
Szolnoki Zoltan, Kondacs Andras, Mandi Yvette, Bodor Anita, Somogyvari Ferenc
Abstract excerpt
Multiple sclerosis (MS), which results in damage of the white matter at multiple foci, poses a far-reaching public health problem in view of the burden it imposes on the affected young and middle-aged. Some previous data suggested that roles could be played in the demyelinization of the white matter of the brain by the malfunctioning of the mitochondria and mitochondria-associated reactive oxygen species. In this...
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