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Article

Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology.

Molecular systems biology - 1 Jan 2009

Cox Brian, Kotlyar Max, Evangelou Andreas I, Ignatchenko Vladimir, Ignatchenko Alex, Whiteley Kathie, Jurisica Igor, Adamson S Lee, Rossant Janet, Kislinger Thomas

Abstract excerpt

Placental abnormalities are associated with two of the most common and serious complications of human pregnancy, maternal preeclampsia (PE) and fetal intrauterine growth restriction (IUGR), each disorder affecting approximately 5% of all pregnancies. An important question for the use of the mouse as a model for studying human disease is the degree of functional conservation of genetic control pathways from human...

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Identifiers

PMID: 19536202
DOI: 10.1038/msb.2009.37
PMCID: PMC2710868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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