Article
Comparative sequence analysis of A-type inclusion (ATI) and P4c proteins of orthopoxviruses that produce typical and atypical ATI phenotypes.
Virus genes - 1 Oct 2009
Okeke Malachy Ifeanyi, Adekoya Olayiwola A, Moens Ugo, Tryland Morten, Traavik Terje, Nilssen Øivind
Abstract excerpt
Some orthopoxviruses produce large proteinaceous intracellular bodies, known as A-type inclusions (ATIs) during infection of host cells. Virions associate with ATIs resulting in distinct phenotypes referred to as V+, V+/ and V⁻. The phenotype V+ has the virions embedded in the ATI matrix; V⁻ has no virions embedded within or on the surface of the ATI matrix, whereas an aberrant phenotype, the V+/ has virions only...
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