Article
Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma.
International journal of colorectal disease - 1 Nov 2009
Schmitz Klaus Jürgen, Müller Carmen Ina, Reis Henning, Alakus Hakan, Winde Günther, Baba Hideo Andreas, Wohlschlaeger Jeremias, Jasani Bharat, Fandrey Joachim, Schmid Kurt Werner
Abstract excerpt
PURPOSE: Hypoxia-inducible factor 1 (HIF-1) is a hypoxia-induced transcription factor that regulates gene expression in critical pathways involved in tumour growth and metastasis. Metallothionein (MT) is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. The present study aimed to analyse the prognostic impact of HIF-1alpha and MT expression in colorectal cancer and to...
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