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DNA methylation patterns of spermatozoa and two generations of offspring obtained after murine spermatogonial stem cell transplantation

12 Jun 2009

Abstract excerpt

BACKGROUND: Apart from its use in research, spermatogonial stem cell transplantation (SSCT) may have important clinical applications. This controlled study aimed at evaluating the safety of SSCT by analyzing the DNA methylation pattern of Igf2, Peg1 and alpha-Actin both in spermatozoa and live born offspring obtained after SSCT in mice. METHODS: Testicular cell suspensions were transplanted to the testes of...

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Share to Epigenetics and DNA Methylation
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PMID: 19525299
DOI: 10.1093/humrep/dep213

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