High frequency of clinically significant mutations after first-line generic highly active antiretroviral therapy failure: implications for second-line options in resource-limited settings.

doi:10.1086/600044

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High frequency of clinically significant mutations after first-line generic highly active antiretroviral therapy failure: implications for second-line options in resource-limited settings.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jul 2009

Kumarasamy N, Madhavan Vidya, Venkatesh Kartik K, Saravanan S, Kantor Rami, Balakrishnan P, Devaleenal Bella, Poongulali S, Yepthomi Tokugha, Solomon Suniti, Mayer Kenneth H, Benson Constance, Schooley Robert

Abstract excerpt

Continuation of failed highly active antiretroviral therapy regimens can lead to the accumulation of mutations that may limit options for second-line treatment. We studied the pattern of drug resistance mutations among 138 Indian patients who experienced failure of nonnucleotide reverse-transcriptase-containing first-line highly active antiretroviral therapy. This study demonstrates a high frequency of drug...

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PMID: 19522657
DOI: 10.1086/600044
PMCID: PMC8559152

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