Article
Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen.
PLoS pathogens - 1 Jun 2009
Larsson Pär, Elfsmark Daniel, Svensson Kerstin, Wikström Per, Forsman Mats, Brettin Thomas, Keim Paul, Johansson Anders
Abstract excerpt
Francisella tularensis is a potent mammalian pathogen well adapted to intracellular habitats, whereas F. novicida and F. philomiragia are less virulent in mammals and appear to have less specialized lifecycles. We explored adaptations within the genus that may be linked to increased host association, as follows. First, we determined the genome sequence of F. tularensis subsp. mediasiatica, the only subspecies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.