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Article

Structure, properties, and engineering of the major zinc binding site on human albumin.

The Journal of biological chemistry - 21 Aug 2009

Blindauer Claudia A, Harvey Ian, Bunyan Kerry E, Stewart Alan J, Sleep Darrell, Harrison David J, Berezenko Stephen, Sadler Peter J

Abstract excerpt

Most blood plasma zinc is bound to albumin, but the structure of the binding site has not been determined. Zn K-edge extended x-ray absorption fine structure spectroscopy and modeling studies show that the major Zn(2+) site on albumin is a 5-coordinate site with average Zn-O/N distances of 1.98 A and a weak sixth O/N bond of 2.48 A, consistent with coordination to His(67) and Asn(99) from domain I, His(247) and...

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Identifiers

PMID: 19520864
DOI: 10.1074/jbc.M109.003459
PMCID: PMC2755717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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