Article
Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2009
Ruigrok Ynte M, Rinkel Gabriel J E, Wijmenga Cisca, Kasuya Hidetoshi, Tajima Atsushi, Takahashi Tomoko, Hata Akira, Inoue Ituro, Krischek Boris
Abstract excerpt
BACKGROUND: An association between versican (CSPG2), perlecan (HSPG2), fibrillin 2 (FBN2) and collagen 4A1 (COL4A1) gene variants and intracranial aneurysms (IA) has been reported in 2 studies analyzing Dutch IA patients. The aim of this study was to verify these associations in a Japanese IA population. In addition, a meta-analysis on the association of these genes and IA for the combined Dutch and Japanese...
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