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Article

MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos.

Development (Cambridge, England) - 1 Jul 2009

Ruzov Alexey, Shorning Boris, Mortusewicz Oliver, Dunican Donncha S, Leonhardt Heinrich, Meehan Richard R

Abstract excerpt

Loss of the of the maintenance methyltransferase xDNMT1 during Xenopus development results in premature transcription and activation of a p53-dependent apoptotic program that accounts for embryo lethality. Here, we show that activation of the apoptotic response is signalled through the methyl-CpG binding protein xMBD4 and the mismatch repair pathway protein xMLH1. Depletion of xMBD4 or xMLH1 increases the...

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Share to DNA (Cytosine-5-)-Methyltransferase 1
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19502488
DOI: 10.1242/dev.032227
PMCID: PMC2729342

Genes

DNMT1
MBD4
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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