Article
Role of genetic susceptibility to latent adenoviral infection and decreased lung function.
Respiratory medicine - 1 Nov 2009
Kasuga Ikuma, Hogg James C, Paré Peter D, Hayashi Shizu, Sedgwick Edward G, Ruan Jian, Wallace Alison M, He Jian-Qing, Zhang Xiaozhu, Sandford Andrew J
Abstract excerpt
BACKGROUND: Latent adenoviral infection may amplify cigarette smoke-induced lung inflammation and therefore play an important role in the development of chronic obstructive pulmonary disease (COPD). Adenoviruses can evade the human immune response via their 19-kDa protein (19K) which delays the expression of class I human leukocyte antigen (HLA) proteins. The 19K protein shows higher affinity to HLA-B7 and A2...
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