Article
Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma <i>In situ</i> Is an Arrested Gonocyte
2 Jun 2009
Abstract excerpt
Testicular germ cell cancers in young adult men derive from a precursor lesion called carcinoma in situ (CIS) of the testis. CIS cells were suggested to arise from primordial germ cells or gonocytes. However, direct studies on purified samples of CIS cells are lacking. To overcome this problem, we performed laser microdissection of CIS cells. Highly enriched cell populations were obtained and subjected to gene...
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