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Article

A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus.

The Journal of biological chemistry - 7 Aug 2009

Crispin Max, Chang Veronica T, Harvey David J, Dwek Raymond A, Evans Edward J, Stuart David I, Jones E Yvonne, Lord J Michael, Spooner Robert A, Davis Simon J

Abstract excerpt

Disruption of Golgi alpha-mannosidase II activity can result in type II congenital dyserythropoietic anemia and induce lupus-like autoimmunity in mice. Here, we isolated a mutant human embryonic kidney (HEK) 293T cell line called Lec36, which displays sensitivity to ricin that lies between the parental HEK 293T cells, in which the secreted and membrane-expressed proteins are dominated by complex-type...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19465480
DOI: 10.1074/jbc.M109.006254
PMCID: PMC2755891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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