Article
Crystal Structure and Metal Binding Properties of the Lipoprotein MtsA, Responsible for Iron Transport in <i>Streptococcus pyogenes</i>
22 May 2009
Abstract excerpt
An ability to acquire iron is essential for the viability and growth of almost all organisms and in pathogenic bacteria is strongly correlated with virulence. The cell surface lipoprotein MtsA, a component of the MtsABC transporter of Streptococcus pyogenes, acts as the primary receptor for inorganic iron by this significant human pathogen. Iron is bound as Fe(2+), with the participation of bicarbonate. The...
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