Article
Molecular profiling of the "plexinome" in melanoma and pancreatic cancer.
Human mutation - 1 Aug 2009
Balakrishnan Asha, Penachioni Junia Y, Lamba Simona, Bleeker Fonnet E, Zanon Carlo, Rodolfo Monica, Vallacchi Viviana, Scarpa Aldo, Felicioni Lara, Buck Matthias, Marchetti Antonio, Comoglio Paolo M, Bardelli Alberto, Tamagnone Luca
Abstract excerpt
Plexins are transmembrane high-affinity receptors for semaphorins, regulating cell guidance, motility, and invasion. Functional evidences implicate semaphorin signals in cancer progression and metastasis. Yet, it is largely unknown whether plexin genes are genetically altered in human tumors. We...
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