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Article

Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors.

Journal of medical genetics - 1 Jul 2009

Futter M, Diekmann H, Schoenmakers E, Sadiq O, Chatterjee K, Rubinsztein D C

Abstract excerpt

BACKGROUND: Huntington's disease is caused by expansion of a polyglutamine tract found in the amino-terminal of the ubiquitously expressed protein huntingtin. Well studied in its mutant form, huntingtin has a wide variety of normal functions, loss of which may also contribute to disease progression. Widespread transcriptional dysfunction occurs in brains of Huntington's disease patients and in transgenic mouse...

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Source

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Identifiers

PMID: 19451134
DOI: 10.1136/jmg.2009.066399
PMCID: PMC2696822

Genes

ABCA1
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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