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Article

Comparative proteome analysis to explore p53 pathway disruption in head and neck carcinogenesis.

Journal of proteomics - 21 Jul 2009

Schaaij-Visser Tieneke B M, Brakenhoff Ruud H, Jansen Jeroen W A, O'Flaherty Martina C, Smeets Serge J, Heck Albert J R, Slijper Monique

Abstract excerpt

The 5-year-survival rate of head and neck squamous cell carcinoma (HNSCC) has been only moderately improved over the last few decades. HNSCC develops in precursor fields of genetically altered mucosal cells, typically characterized by p53 pathway disruption, that mostly do not give any clinical symptoms. Patients present therefore often with invasive carcinomas in an advanced stage. After tumor resection, part of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19446051
DOI: 10.1016/j.jprot.2009.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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