Article
BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance.
The British journal of dermatology - 1 Aug 2009
Da Forno P D, Pringle J H, Fletcher A, Bamford M, Su L, Potter L, Saldanha G
Abstract excerpt
BACKGROUND: The relationships between so-called spitzoid tumours have proven difficult to understand. OBJECTIVES: To address three questions: does spitzoid tumour morphological similarity reflect molecular similarity? Does Spitz naevus progress into spitzoid melanoma? Are ambiguous spitzoid tumours genuine entities? METHODS: BRAF, NRAS and HRAS mutations were analysed using single-strand conformational...
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