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Article

The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes.

PLoS pathogens - 1 May 2009

Tan Jinzhi, Vonrhein Clemens, Smart Oliver S, Bricogne Gerard, Bollati Michela, Kusov Yuri, Hansen Guido, Mesters Jeroen R, Schmidt Christian L, Hilgenfeld Rolf

Abstract excerpt

Since the outbreak of severe acute respiratory syndrome (SARS) in 2003, the three-dimensional structures of several of the replicase/transcriptase components of SARS coronavirus (SARS-CoV), the non-structural proteins (Nsps), have been determined. However, within the large Nsp3 (1922 amino-acid residues), the structure and function of the so-called SARS-unique domain (SUD) have remained elusive. SUD occurs only...

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Identifiers

PMID: 19436709
DOI: 10.1371/journal.ppat.1000428
PMCID: PMC2674928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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