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Identification of the SARS-unique domain of SARS-CoV-2 as an antiviral target

6 Jul 2023

Abstract excerpt

Abstract SARS-CoV-2 nsp3 is essential for viral replication and host responses. The SARS-unique domain (SUD) of nsp3 exerts its function through binding to viral and host proteins and RNAs. Herein, we show that SARS-CoV-2 SUD is highly flexible in solution. The intramolecular disulfide bond of SARS-CoV SUD is absent in SARS-CoV-2 SUD. Incorporating this bond in SARS-CoV-2 SUD allowed crystal structure...

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Share to Bacteriophages and microbial interactions
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PMID: 37414753
DOI: 10.1038/s41467-023-39709-6

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