Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum.

Journal of medical microbiology - 1 Jun 2009

Matějková Petra, Flasarová Magdalena, Zákoucká Hana, Bořek Milan, Křemenová Soňa, Arenberger Petr, Woznicová Vladana, Weinstock George M, Šmajs David

Abstract excerpt

We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Czech Republic
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrolides

Share to Rabbits

Share to RNA, Ribosomal, 23S

Share to Syphilis

Share to Treatment Failure

Share to Treponema pallidum

Source

Identifiers

PMID: 19429763
DOI: 10.1099/jmm.0.007542-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum.PMID 19429763Read ↗

High frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis.Semantic proximity Read ↗

Azithromycin resistance in Treponema pallidumSemantic proximity Read ↗

Prevalence of the 23S rRNA A2058G Point Mutation and Molecular Subtypes in Treponema pallidum in the United States, 2007 to 2009Semantic proximity Read ↗

Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains?Semantic proximity Read ↗

First Report of the 23S rRNA Gene A2058G Point Mutation Associated With Macrolide Resistance in Treponema pallidum From Syphilis Patients in Cuba.Semantic proximity Read ↗

Multicentre surveillance of prevalence of the 23S rRNA A2058G and A2059G point mutations and molecular subtypes of Treponema pallidum in Taiwan, 2009-2013.Semantic proximity Read ↗

Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains.Semantic proximity Read ↗

Clarithromycin treatment failure due to macrolide resistance in Treponema pallidum in a patient with primary syphilis.Semantic proximity Read ↗

Resistance to ceftriaxone and penicillin G among contemporary syphilis strains confirmed by natural in vitro mutagenesisSemantic proximity Read ↗

Two Mutations Associated With Macrolide Resistance in Treponema pallidumSemantic proximity Read ↗

Molecular Subtyping and Surveillance of Resistance Genes In Treponema pallidum DNA From Patients With Secondary and Latent Syphilis in Hunan, China.Semantic proximity Read ↗

Azithromycin treatment failure among primary and secondary syphilis patients in Shanghai.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.