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Two Mutations Associated With Macrolide Resistance in Treponema pallidum

20 Nov 2012

Abstract excerpt

BACKGROUND: Although azithromycin promised to be a safe and effective single-dose oral treatment of early syphilis, azithromycin treatment failure has been documented and is associated with mutations in the 23S rDNA of corresponding Treponema pallidum strains. The prevalence of strains harboring these mutations varies throughout the United States and the world. We examined T. pallidum strains circulating in...

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PMID: 23191949
DOI: 10.1097/olq.0b013e31826ae7a8

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