Article
Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains.
Sexually transmitted diseases - 1 Sept 2016
Molini Barbara J, Tantalo Lauren C, Sahi Sharon K, Rodriguez Veronica I, Brandt Stephanie L, Fernandez Mark C, Godornes Charmie B, Marra Christina M, Lukehart Sheila A
Abstract excerpt
BACKGROUND: High rates of 23S rDNA mutations implicated in macrolide resistance have been identified in Treponema pallidum samples from syphilis patients in many countries. Nonetheless, some clinicians have been reluctant to abandon azithromycin as a treatment for syphilis, citing the lack of a causal association between these mutations and clinical evidence of drug resistance. Although azithromycin resistance...
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