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Article

No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib.

Leukemia research - 1 Feb 2006

Politou Marianna, Karadimitris Anastasios, Terpos Evangelos, Kotsianidis Ioannis, Apperley Jane F, Rahemtulla Amin

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Share to Antineoplastic Agents
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Share to Bortezomib
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Myeloma

Share to Protease Inhibitors

Share to Proteasome Endopeptidase Complex

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Source

Identifiers

PMID: 16081156
DOI: 10.1016/j.leukres.2005.06.014

Genes

PSMB5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Research trail→

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No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib.PMID 16081156Read ↗

Spectrum and functional validation of PSMB5 mutations in multiple myeloma.Semantic proximity Read ↗

Bortezomib resistance mutations in PSMB5 determine response to second-generation proteasome inhibitors in multiple myelomaSemantic proximity Read ↗

Updates to the drug‐resistant mechanism of proteasome inhibitors in multiple myelomaSemantic proximity Read ↗

Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.Semantic proximity Read ↗

Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple MyelomaSemantic proximity Read ↗

Genetic Alterations in Members of the Proteasome 26S Subunit, AAA-ATPase (PSMC) Gene Family in the Light of Proteasome Inhibitor Resistance in Multiple MyelomaSemantic proximity Read ↗

Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.Semantic proximity Read ↗

Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress.Semantic proximity Read ↗

Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone.Semantic proximity Read ↗

Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line.Semantic proximity Read ↗

The Prognostic Value of Whole-Blood PSMB5, CXCR4, POMP and RPL5 mRNA Expression in Patients with Multiple Myeloma Treated with BortezomibSemantic proximity Read ↗

Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma CellsSemantic proximity Read ↗

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