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Article

Expression of cystathionine β-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis

6 May 2009

Abstract excerpt

The cystathionine beta-synthase (CBS) gene encodes an enzyme that catalyzes the synthesis of cystathionine in the trans-sulfuration pathway and is subject to tight regulation because of its critical role in antioxidant and methylation metabolism. The expression level of CBS in 120 hepatocellular carcinoma (HCC) specimens evaluated by real-time reverse transcriptase PCR (RT-PCR) is markedly lower than in...

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PMID: 19424622
DOI: 10.3892/or_00000373

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