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Article

Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder.

Pharmacogenetics and genomics - 1 May 2009

McHugh Patrick C, Joyce Peter R, Kennedy Martin R

Abstract excerpt

OBJECTIVES: In a previous investigation, we observed altered expression of sepiapterin reductase (SPR) in cultured neural cells chronically exposed to paroxetine. SPR is an enzyme, which catalyzes the final step in the synthesis of tetrahydrobiopterin (BH4). BH4 is an essential cofactor for synthesis of many neurotransmitters including serotonin. Given the pivotal role of SPR in neurotransmitter production, we...

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Identifiers

PMID: 19415819
DOI: 10.1097/fpc.0b013e328328f82c

Genes

SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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