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Article

Lentivector immunization stimulates potent CD8 T cell responses against melanoma self-antigen tyrosinase-related protein 1 and generates antitumor immunity in mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2009

Liu Yanjun, Peng Yibing, Mi Michael, Guevara-Patino Jose, Munn David H, Fu Ning, He Yukai

Abstract excerpt

Recombinant lentivector immunization has been demonstrated to induce potent CD8 T cell responses in vivo. In this study, we investigated whether lentivector delivering a self/tumor Ag, tyrosinase related protein 1 (TRP1), could stimulate effective antitumor T cell responses. We found that immunization with lentivector expressing mutated TRP1 Ag elicited potent CD8 T cell responses against multiple TRP1 epitopes....

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Identifiers

PMID: 19414747
DOI: 10.4049/jimmunol.0900008
PMCID: PMC3077746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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