Article
Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa.
PLoS pathogens - 1 Aug 2020
Honeycutt Jared D, Wenner Nicolas, Li Yan, Brewer Susan M, Massis Liliana M, Brubaker Sky W, Chairatana Phoom, Owen Siân V, Canals Rocío, Hinton Jay C D, Monack Denise M
Abstract excerpt
The various sub-species of Salmonella enterica cause a range of disease in human hosts. The human-adapted Salmonella enterica serovar Typhi enters the gastrointestinal tract and invades systemic sites to cause enteric (typhoid) fever. In contrast, most non-typhoidal serovars of Salmonella are primarily restricted to gut tissues. Across Africa, invasive non-typhoidal Salmonella (iNTS) have emerged with an ability...
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