Article
Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population.
BMB reports - 30 Apr 2009
Park Sun Ah, Park Byung Lae, Park Jeong Ho, Lee Tae Kyeong, Sung Ki Bum, Lee You Kyoung, Chang Hun Soo, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
Thromboxane A2 (TBXA2) is a potent vasoconstrictor in cerebral circulation and is a known contributor to the pathogenesis of cerebral infarction. Thromboxane A2 synthase 1 (TBXAS1) and thromboxane A2 receptors (TBXA2R) are key components in TBXA2 function. We examined whether genetic variants in TBXA2R and TBXAS1 are risk factors for cerebral infarction by genotyping 453 Korean patients with noncardiogenic...
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