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Antiviral resistance and hepatitis B therapy #

1 May 2009

Abstract excerpt

The management of chronic hepatitis B currently rests with long-term therapy using oral nucleoside analogs. The major limitation of long-term therapy is antiviral resistance. Antiviral resistance is due to the high rate of mutations that can occur during hepatitis B virus (HBV) replication and the selection of these mutants due to a replication advantage in the presence of the antiviral agent. Indeed, high rates...

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PMID: 19399794
DOI: 10.1002/hep.22900

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