Article
Frequent genetic changes in childhood pheochromocytomas.
Annals of the New York Academy of Sciences - 1 Aug 2006
De Krijger Ronald R, Petri Bart-Jeroen, Van Nederveen Francien H, Korpershoek Esther, De Herder Wouter W, De Muinck Keizer-Schrama Sabine M P F, Dinjens Winand N M
Abstract excerpt
Pheochromocytomas (PCCs) are rare catecholamine-producing tumors of the adrenal gland which may also occur elsewhere in the abdomen and are then called paragangliomas. A proportion of PCCs occurs in hereditary cancer syndromes, including multiple endocrine neoplasia Type 2 (MEN2), caused by mutations in the RET proto-oncogene, von Hippel-Lindau (VHL) disease, caused by VHL gene abnormalities, and the...
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