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Article

Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy.

Journal of immunological methods - 30 Jun 2009

Klapper Jacob A, Thomasian Armen A, Smith Douglas M, Gorgas Gayle C, Wunderlich John R, Smith Franz O, Hampson Brian S, Rosenberg Steven A, Dudley Mark E

Abstract excerpt

Adoptive cell therapy (ACT) for metastatic melanoma involves the ex vivo expansion and reinfusion of tumor infiltrating lymphocytes (TIL) obtained from resected specimens. With an overall objective response rate of 56%, this T-cell immunotherapy provides an appealing alternative to other therapie...

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Identifiers

PMID: 19389403
DOI: 10.1016/j.jim.2009.04.009
PMCID: PMC2700005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19389403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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