Article
Loss of heterozygosity at the FLCN locus in early renal cystic lesions in dogs with renal cystadenocarcinoma and nodular dermatofibrosis.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2009
Bønsdorff Tina B, Jansen Johan H, Thomassen Ragnar F, Lingaas Frode
Abstract excerpt
Small, macroscopically visible cysts on the surface of the kidneys were observed in eight 6-8-week-old puppies diagnosed with renal cystadenocarcinoma and nodular dermatofibrosis (RCND). Histologic examination of the renal cortices in these puppies reveals numerous small cystic tubular changes. Hyperplastic change of the epithelial lining of cysts is frequently observed. By laser-capture microdissection we have...
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