Article
Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes.
Nucleic acids research - 1 Jul 2009
Kippenberger Stefan, Müller Jutta, Schultz Maike, Dorn Annette, Bock Andreas, Aygün Hüseyin, Thaçi Diamant, Hofmann Matthias, Kaufmann Roland, Bernd August
Abstract excerpt
DNA oligonucleotides (ODN) applied to an organism are known to modulate the innate and adaptive immune system. Previous studies showed that a CpG-containing ODN (CpG-1-PTO) and interestingly, also a non-CpG-containing ODN (nCpG-5-PTO) suppress inflammatory markers in skin. In the present study it was investigated whether these molecules also influence cell apoptosis. Here we show that CpG-1-PTO, nCpG-5-PTO, and...
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