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Article

p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature.

Mutagenesis - 1 May 2012

De Feo Emma, Simone Benedetto, Kamgaing Rachel Simo, Gallì Paola, Hamajima Nobuyuki, Hu Zhibin, Li Guojun, Li Yan, Matsuo Keitaro, Park Jae Yong, Roychoudhury Susanta, Spitz Margaret R, Wei Qingyi, Zhang Jian-Hui, Ricciardi Walter, Boccia Stefania

Abstract excerpt

The p73 gene (1p36-33) is involved in cancer development through cell growth inhibition by inducing apoptosis in a p53-like manner. The p73 G4C14-to-A4T14 dinucleotide polymorphism, consisting of two single-nucleotide polymorphisms in the non-coding region of exon 2 that are in complete linkage disequilibrium, has been extensively studied in association with cancer risk. We performed a meta-analysis of published...

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PMID: 21976716
DOI: 10.1093/mutage/ger065

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