Article
Small effect of the androgen receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men.
European journal of endocrinology - 1 Jul 2009
Bogaert Veerle, Vanbillemont Griet, Taes Youri, De Bacquer Dirk, Deschepper Ellen, Van Steen Kristel, Kaufman Jean-Marc
Abstract excerpt
OBJECTIVE: The human androgen receptor (AR) contains a polyglutamine and a polyglycine stretch which are highly polymorphic and are coded respectively by a CAG and GGN repeat in exon 1 of the AR gene. Although the in vitro studies indicated a possible effect of the GGN repeat polymorphism on the AR gene transcription and clinical observations suggest that it might modulate the androgen action, its functional...
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