Article
Host Wnt/beta-catenin pathway triggered by Helicobacter pylori correlates with regression of gastric intestinal metaplasia after H. pylori eradication.
Journal of medical microbiology - 1 May 2009
Hung Kuei-Hsiang, Wu Jiunn-Jong, Yang Hsiao-Bai, Su Li-Ju, Sheu Bor-Shyang
Abstract excerpt
Helicobacter pylori eradication can reverse gastric intestinal metaplasia (IM) in some but not all patients. H. pylori induces high levels of nuclear beta-catenin staining in IM tissues, as well as overexpression of cyclooxygenase-2 (COX-2). This study investigated whether the Wnt/beta-catenin pathway plays a role in IM regression following H. pylori eradication. Sixty-five H. pylori-infected patients with IM who...
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