Article
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
Journal of clinical pathology - 1 Aug 2007
Watari J, Tanaka A, Tanabe H, Sato R, Moriichi K, Zaky A, Okamoto K, Maemoto A, Fujiya M, Ashida T, Das K M, Kohgo Y
Abstract excerpt
BACKGROUND: Helicobacter pylori related gastric intestinal metaplasia (IM) is considered to be a precancerous lesion. AIMS: To identify the effects of H pylori eradication on K-ras mutations, cell kinetics in IM and histological changes in patients with and without gastric cancers in a one-year prospective study. METHODS: Patients included group A (n = 39), chronic gastritis, and group B (n = 53), intestinal-type...
Topics
- Apoptosis
- Cell Division
- Chronic Disease
- Codon
- Gastritis
- Genes, ras
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Metaplasia
- Mutation
- Neutrophils
- Precancerous Conditions