Article
A library of mutated Maackia amurensis hemagglutinin distinguishes putative glycoforms of immunoglobulin A1 from IgA nephropathy patients.
Journal of proteome research - 1 Jul 2009
Maenuma Keisuke, Yim Mijung, Komatsu Kunimitsu, Hoshino Mayumi, Tachiki-Fujioka Ayumi, Takahashi Kazuo, Hiki Yoshiyuki, Bovin Nicolai, Irimura Tatsuro
Abstract excerpt
Ten genetically modified Maackia amurensis hemagglutinin (MAH) clones at the carbohydrate-recognition loop were found to bind glycophorin A and a mucin mimetic with NeuAcalpha2-3Galbeta1-3GalNAcalpha (monosialyl-T antigen) in different relative intensity. Binding profiles of these lectins to human serum IgA1 from healthy individuals and from IgA nephropathy patients were subjected to the cluster analysis. Two...
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