Article
Effect of varying epistasis on the evolution of recombination.
Genetics - 1 Jun 2006
Kouyos Roger D, Otto Sarah P, Bonhoeffer Sebastian
Abstract excerpt
Whether recombination decelerates or accelerates a population's response to selection depends, at least in part, on how fitness-determining loci interact. Realistically, all genomes likely contain fitness interactions both with positive and with negative epistasis. Therefore, it is crucial to determine the conditions under which the potential beneficial effects of recombination with negative epistasis prevail...
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